LINCS: Assessment of NIH Common Fund Resources with C2M2
Tags: nihcommonfund
URL(s):
- https://commonfund.nih.gov/lincs
- http://www.lincsproject.org/
- http://lincsportal.ccs.miami.edu/datasets/
- https://github.com/nih-cfde/FAIR/tree/master/LINCS
Project Assessments (2243)
| Assessment | Metrics | Date | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Target | Rubric | NIH program name is available for querying | NIH project name is available for querying | Machine-readable metadata | The institution that created this dataset is available | A biological assay is present and resolvable in CFDE-specified ontology (OBI) | A relevant anatomical part is present and resolvable in the UBERON Ontology | Open, Free, Standardized Access protocol | A relevant disease is present and resolvable in the MONDO Ontology | A relevant file type is present and resolvable in the EDAM Ontology | A relevant taxonomy is present and resolvable in the NCBITaxon Ontology | A relevant cell line is present and resolvable in the Cellosaurus Ontology | Globally unique identifier | Digital resource license | Resource identifier in metadata | A landing page exists and is accessible | Metadata license | Contact information is provided for the creator(s) of the dataset. | ||
| GSK-1838705A KINOMEscan | NIH Common Fund Data Ecosystem (CFDE) FAIR Rubric |
|
no (0.00) | yes (1.00) | no (0.00) | yes (1.00) | nobut (0.25) | no (0.00) | yes (1.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | yesbut (0.75) | yes (1.00) | yes (1.00) | yes (1.00) | Sep 25, 2019 |
| Growth rate-corrected (GR) dose-response metric signatures across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 4 of 4: Median, upper quartile, and lower quartile GR metrics per perturbagen class. | NIH Common Fund Data Ecosystem (CFDE) FAIR Rubric |
|
no (0.00) | yes (1.00) | yesbut (0.72) | yes (1.00) | no (0.00) | no (0.00) | yes (1.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | yesbut (0.75) | yes (1.00) | yes (1.00) | yes (1.00) | Sep 25, 2019 |
| XMD13-2 KINOMEscan | NIH Common Fund Data Ecosystem (CFDE) FAIR Rubric |
|
no (0.00) | yes (1.00) | no (0.00) | yes (1.00) | nobut (0.25) | no (0.00) | yes (1.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | yesbut (0.75) | yes (1.00) | yes (1.00) | yes (1.00) | Sep 25, 2019 |
| LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 7 of 15: Mean cell count and mean growth rate across all replicates. | NIH Common Fund Data Ecosystem (CFDE) FAIR Rubric |
|
no (0.00) | yes (1.00) | no (0.00) | yes (1.00) | nobut (0.25) | no (0.00) | yes (1.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | yesbut (0.75) | yes (1.00) | yes (1.00) | yes (1.00) | Sep 25, 2019 |
| Sorafenib KINOMEscan | NIH Common Fund Data Ecosystem (CFDE) FAIR Rubric |
|
no (0.00) | yes (1.00) | no (0.00) | yes (1.00) | nobut (0.25) | no (0.00) | yes (1.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | yesbut (0.75) | yes (1.00) | yes (1.00) | yes (1.00) | Sep 25, 2019 |
| MGH (CMT) Growth Inhibition Assay Protocol (9 compound doses: 8 uM to 0.03125 uM) -- DNA Staining | NIH Common Fund Data Ecosystem (CFDE) FAIR Rubric |
|
no (0.00) | yes (1.00) | no (0.00) | yes (1.00) | nobut (0.25) | no (0.00) | yes (1.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | yesbut (0.75) | yes (1.00) | yes (1.00) | yes (1.00) | Sep 25, 2019 |
| PD173074 KINOMEscan | NIH Common Fund Data Ecosystem (CFDE) FAIR Rubric |
|
no (0.00) | yes (1.00) | no (0.00) | yes (1.00) | nobut (0.25) | no (0.00) | yes (1.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | yesbut (0.75) | yes (1.00) | yes (1.00) | yes (1.00) | Sep 25, 2019 |
| Growth factor-induced FoxO3a nuclear-cytoplasmic pulsing dynamics of non-phosphorylatable reporters in mammary epithelial cell lines. Dataset 3 of 3: mean reporter pulsing metrics. | NIH Common Fund Data Ecosystem (CFDE) FAIR Rubric |
|
no (0.00) | yes (1.00) | maybe (0.40) | yes (1.00) | nobut (0.25) | no (0.00) | yes (1.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | yesbut (0.75) | yes (1.00) | yes (1.00) | yes (1.00) | Sep 25, 2019 |
| Metrics for growth responses of MDA-MB-231 and HME-1 cell lines to LINCS Pilot Phase TransCenter Project kinase inhibitors | NIH Common Fund Data Ecosystem (CFDE) FAIR Rubric |
|
no (0.00) | yes (1.00) | no (0.00) | yes (1.00) | nobut (0.25) | no (0.00) | yes (1.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | yesbut (0.75) | yes (1.00) | yes (1.00) | yes (1.00) | Sep 25, 2019 |
| Growth factor-induced ERK activity pulsing dynamics in a mammary epithelial cell line. Dataset 2 of 3: single-cell reporter pulsing metrics. | NIH Common Fund Data Ecosystem (CFDE) FAIR Rubric |
|
no (0.00) | yes (1.00) | maybe (0.56) | yes (1.00) | nobut (0.25) | no (0.00) | yes (1.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | yesbut (0.75) | yes (1.00) | yes (1.00) | yes (1.00) | Sep 25, 2019 |
| XMD16-144 KINOMEscan | NIH Common Fund Data Ecosystem (CFDE) FAIR Rubric |
|
no (0.00) | yes (1.00) | no (0.00) | yes (1.00) | nobut (0.25) | no (0.00) | yes (1.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | yesbut (0.75) | yes (1.00) | yes (1.00) | yes (1.00) | Sep 25, 2019 |
| Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. | NIH Common Fund Data Ecosystem (CFDE) FAIR Rubric |
|
no (0.00) | yes (1.00) | no (0.00) | yes (1.00) | no (0.00) | no (0.00) | yes (1.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | yesbut (0.75) | yes (1.00) | yes (1.00) | yes (1.00) | Sep 25, 2019 |
| Ibrutinib KINOMEscan | NIH Common Fund Data Ecosystem (CFDE) FAIR Rubric |
|
no (0.00) | yes (1.00) | no (0.00) | yes (1.00) | nobut (0.25) | no (0.00) | yes (1.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | yesbut (0.75) | yes (1.00) | yes (1.00) | yes (1.00) | Sep 25, 2019 |
| IGF-I-induced FoxO3a nuclear-cytoplasmic pulsing dynamics in mammary epithelial cell lines following treatment with increasing doses of an AKT inhibitor. Dataset 1 of 3: single-cell reporter measurements. | NIH Common Fund Data Ecosystem (CFDE) FAIR Rubric |
|
no (0.00) | yes (1.00) | no (0.00) | yes (1.00) | nobut (0.25) | no (0.00) | yes (1.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | yesbut (0.75) | yes (1.00) | yes (1.00) | yes (1.00) | Sep 25, 2019 |
| Flavopiridol KINOMEscan | NIH Common Fund Data Ecosystem (CFDE) FAIR Rubric |
|
no (0.00) | yes (1.00) | no (0.00) | yes (1.00) | nobut (0.25) | no (0.00) | yes (1.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | yesbut (0.75) | yes (1.00) | yes (1.00) | yes (1.00) | Sep 25, 2019 |
| PHA-793887 KINOMEscan | NIH Common Fund Data Ecosystem (CFDE) FAIR Rubric |
|
no (0.00) | yes (1.00) | no (0.00) | yes (1.00) | nobut (0.25) | no (0.00) | yes (1.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | yesbut (0.75) | yes (1.00) | yes (1.00) | yes (1.00) | Sep 25, 2019 |
| Taselisib KINOMEscan | NIH Common Fund Data Ecosystem (CFDE) FAIR Rubric |
|
no (0.00) | yes (1.00) | no (0.00) | yes (1.00) | nobut (0.25) | no (0.00) | yes (1.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | yesbut (0.75) | yes (1.00) | yes (1.00) | yes (1.00) | Sep 25, 2019 |
| PLX-4720 KINOMEscan | NIH Common Fund Data Ecosystem (CFDE) FAIR Rubric |
|
no (0.00) | yes (1.00) | no (0.00) | yes (1.00) | nobut (0.25) | no (0.00) | yes (1.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | yesbut (0.75) | yes (1.00) | yes (1.00) | yes (1.00) | Sep 25, 2019 |
| Growth rate-corrected (GR) dose-response metric signatures across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 3 of 4: Median, upper quartile, and lower quartile GR metrics per perturbagen. | NIH Common Fund Data Ecosystem (CFDE) FAIR Rubric |
|
no (0.00) | yes (1.00) | no (0.00) | yes (1.00) | no (0.00) | no (0.00) | yes (1.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | yesbut (0.75) | yes (1.00) | yes (1.00) | yes (1.00) | Sep 25, 2019 |
| LINCS MCF 10A Common Project: Fixed-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Repeat performed by Scientist A in 2019 to assess reproducibility. Dataset 2 of 2: Calculated dose response metrics. | NIH Common Fund Data Ecosystem (CFDE) FAIR Rubric |
|
no (0.00) | yes (1.00) | no (0.00) | yes (1.00) | no (0.00) | no (0.00) | yes (1.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | yesbut (0.75) | yes (1.00) | yes (1.00) | yes (1.00) | Sep 25, 2019 |
| IGF-I-induced FoxO3a nuclear-cytoplasmic pulsing dynamics in mammary epithelial cell lines following treatment with increasing doses of an AKT inhibitor. Dataset 3 of 3: mean reporter pulsing metrics. | NIH Common Fund Data Ecosystem (CFDE) FAIR Rubric |
|
no (0.00) | yes (1.00) | no (0.00) | yes (1.00) | nobut (0.25) | no (0.00) | yes (1.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | yesbut (0.75) | yes (1.00) | yes (1.00) | yes (1.00) | Sep 25, 2019 |
| HG-9-91-01 KINOMEscan | NIH Common Fund Data Ecosystem (CFDE) FAIR Rubric |
|
no (0.00) | yes (1.00) | no (0.00) | yes (1.00) | nobut (0.25) | no (0.00) | yes (1.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | yesbut (0.75) | yes (1.00) | yes (1.00) | yes (1.00) | Sep 25, 2019 |
| Metrics other than potency reveal systematic variation in responses to cancer drugs | NIH Common Fund Data Ecosystem (CFDE) FAIR Rubric |
|
no (0.00) | yes (1.00) | no (0.00) | yes (1.00) | nobut (0.25) | no (0.00) | yes (1.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | yesbut (0.75) | yes (1.00) | yes (1.00) | yes (1.00) | Sep 25, 2019 |
| HG-5-113-01 KINOMEscan | NIH Common Fund Data Ecosystem (CFDE) FAIR Rubric |
|
no (0.00) | yes (1.00) | no (0.00) | yes (1.00) | nobut (0.25) | no (0.00) | yes (1.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | yesbut (0.75) | yes (1.00) | yes (1.00) | yes (1.00) | Sep 25, 2019 |
| MEMA YAPC Staining Set 3 | NIH Common Fund Data Ecosystem (CFDE) FAIR Rubric |
|
no (0.00) | yes (1.00) | no (0.00) | yes (1.00) | nobut (0.25) | no (0.00) | yes (1.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | no (0.00) | yesbut (0.75) | yes (1.00) | yes (1.00) | yes (1.00) | Sep 25, 2019 |
