UniProt KnowledgeBase


The UniProt Knowledgebase (UniProtKB) is the central hub for the collection of functional information on proteins, with accurate, consistent and rich annotation. In addition to capturing the core data mandatory for each UniProtKB entry (mainly, the amino acid sequence, protein name or description, taxonomic data and citation information), as much annotation information as possible is added. This includes widely accepted biological ontologies, classifications and cross-references, and clear indications of the quality of annotation in the form of evidence attribution of experimental and computational data. The UniProt Knowledgebase consists of two sections: a reviewed section containing manually-annotated records with information extracted from literature and curator-evaluated computational analysis (aka "UniProtKB/Swiss-Prot"), and an unreviewed section with computationally analyzed records that await full manual annotation (aka "UniProtKB/TrEMBL").

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Associated Projects (2)

FAIRness of Repositories and Datasets Listed on DataMed


FAIR evaluation of the repositories and datasets listed on the BioCADDIE DataMed Resource


FAIRness of FAIRsharing Databases


FAIR evaluation of the FAIRsharing databases


Associated Rubrics (2)

The FAIRshake repository rubric


An initial rubric for asking questions about repositories.

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FAIRSharing Rubric